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Chromosome 3 open reading frame 38 (C3orf38)

Target
C3orf38
Molecular classification
Other (protein with domain of unknown function DUF4518)
01

Overview

Chromosome 3 open reading frame 38 (C3orf38) is a protein in humans encoded by the C3orf38 gene. It is 329 amino acids in length and is uncharacterized, but contains a domain of unknown function (DUF4518), which is part of the protein family pfam15008. The protein may be involved in the regulation of apoptosis and has been proposed as a potential tumor suppressor in some contexts. It shows broad, ubiquitous expression in human tissues and is localized primarily in the cytoplasm and nucleus. Studies suggest C3orf38 may also play a role in metabolic adaptation, particularly related to the response to ketosis. No interacting drugs, biomarker roles, or substantial clinical targeting have been established[1][2][3][4].

Other names
MGC26717LOC285237FLJ54270dense incisors
02

Biological functions

Apoptosis regulationTumor suppressionMetabolic regulation (epigenetically regulated response to ketosis)
03

Disease associations

Cancer (putative tumor suppressor, candidate in ovarian cancer)Other (possible role in metabolic adaptation)

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