Chromosome 4 open reading frame 33 (C4orf33)

Chromosome 4 open reading frame 33 is a protein-coding gene (NCBI Gene ID: 132321; UniProt Q8N1A6) located on 4q28.2 in the human genome. It encodes a small, likely monomeric protein, currently without a defined structure, molecular family, or known biological function in humans[1][2][5]. C4orf33 belongs to a large class of “open reading frame” genes often identified by genome sequencing projects but not functionally characterized. There are no established roles in disease, no evidence for therapeutic targeting, and no widely accepted use as a clinical biomarker. Its expression profile, protein interactions, and regulatory mechanisms remain largely unstudied, placing it in the category of uncharacterized or putative proteins[1][2][5]. In summary, chromosome 4 open reading frame 33 (C4orf33) is a correct but uncharacterized human protein-coding gene with no recognized role as a drug target, biomarker, or disease-associated protein to date[1][2][5][6].

Other names

C4orf33