Target intelligence / Profile preview

Chromosome 4 open reading frame 46 (C4orf46)

Target: C4orf46
Molecular classification: Other (Protein of unknown function, not classified in major target families such as receptors, enzymes, or transporters)

Overview

Chromosome 4 open reading frame 46 (C4orf46), also known as renal cancer differentiation gene 1 (RCDG1), is a small, conserved protein of unknown function encoded by the C4orf46 gene on chromosome 4. The gene is expressed in multiple human tissues, but its molecular and cellular roles remain uncharacterized. Recent clinical research has shown that C4orf46/RCDG1 expression is significantly downregulated in renal cell carcinoma (RCC) tissue compared to adjacent normal tissue, with lower expression in clear cell RCCs and an inverse correlation with tumor grade, suggesting it may have a role in tumor differentiation or progression and could serve as a prognostic biomarker in renal cancer. There are no known drugs, mechanisms of action, or specific safety issues associated with targeting this protein to date, and it is not currently considered a therapeutic target.

Other names: Renal cancer differentiation gene 1 proteinRCDG1LOC201725Renal cancer differentiation gene 1

Mechanism of action

None known (no drugs or biological effectors known to target this protein)

Biological functions

Unknown (no defined biochemical or molecular function in the literature as of current knowledge)Possible role in cell differentiation, particularly in the context of renal cell carcinoma, based on expression correlation

Disease associations

Cancer (specifically, reduced expression in renal cell carcinoma and association with disease grade)Other (no defined causality or mechanistic involvement in other diseases, but associated with some cancers in gene-disease panels)

Safety considerations

None reported (no therapeutic targeting documented, hence no documented safety concerns)

Interacting drugs

None known or reported in the literature

Biomarkers

Possible biomarker for prognosis in renal cell carcinoma (downregulation associated with higher Fuhrman grade and clear cell subtype of renal carcinoma)

Beyond the preview

Go deeper on Chromosome 4 open reading frame 46 (C4orf46).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Chromosome 4 open reading frame 46 (C4orf46).

Explore the full profile