Chromosome 4 open reading frame 50 (C4orf50)

Chromosome 4 open reading frame 50 (C4orf50) is a protein-coding gene located at chromosome 4p16.2 on the minus strand in humans[2]. The protein localizes to the nucleus and is 1508 amino acids long, with calculated molecular mass around 30 kDa and an isoelectric point of 5.6[2]. C4orf50 contains more glutamic acid and arginine, and less phenylalanine and tyrosine than an average human protein[2]. Its predicted structure is rich in alpha helices at the N- and C- termini[2]. Expression levels are low and ubiquitous, but higher in the brain (including the hippocampus and striatum), testis, adrenal, and prostate[2][4]. Post-translational modifications likely include phosphorylation, sulfonation, and glycosylation sites[2]. Evolutionarily, C4orf50 has many vertebrate orthologs but none in invertebrates, and it is relatively rapidly evolving compared to reference proteins[2]. The molecular function and biological roles of C4orf50 remain largely uncharacterized and as yet there is no evidence that it acts as a therapeutic target (such as a receptor, enzyme, transporter, or transcription factor)[2][7][6]. No interacting drugs, known mechanisms of action, established biomarker roles, or notable safety concerns have been reported in the scientific literature. The only disease association is with the genetic disorder Spinocerebellar ataxia 36, but the mechanistic link is unestablished[7]. For these reasons, C4orf50 should be classified under "Other" molecular classification, and there is no conclusive evidence for its involvement in established biological functions, signaling pathways, or as a therapeutic target.

Other names

Uncharacterized protein C4orf50FLJ46481CD050 proteinGC04M006009GC04M005899GC04M005958Q6ZRC1