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Chromosome 5 open reading frame 34 (C5orf34)
- Target
- C5orf34
- Molecular classification
- Protein of unknown function (contains DUF 4520 and DUF 4524 domains), Possible serine/threonine kinase (predicted to have a polo-box domain of polo-like kinase 4), Nuclear protein, Other (no definitive classification as receptor, transporter, etc.)
01
Overview
Chromosome 5 open reading frame 34 (C5orf34) encodes a conserved protein of 638 amino acids in humans, containing two domains of unknown function (DUF 4520 and DUF 4524) and a predicted polo-box domain associated with kinase activity[1]. Its expression is relatively low in most tissues but highest in stomach, intestine, testis, skeletal and heart muscle, and is also detected in dermal fibroblasts[1]. Despite its poorly understood biological function, structural predictions suggest involvement in kinase-related nuclear functions and regulation of cell proliferation[1]. C5orf34 is significantly overexpressed in various cancers and correlates with poor prognosis, likely through influence on the immune microenvironment, making it a candidate prognostic biomarker and a potential therapeutic target[2]. No direct drug interactions, mechanisms of action, or specific safety concerns have been described in the literature[1][2][4].
- Other names
- C5orf34CE034HGNC:24738Ensembl: ENSG00000172244NCBI Gene: 375444UniProtKB: Q96MH7
02
Biological functions
Gene regulation (predicted nuclear localization suggests a regulatory role)Cell proliferation (potential involvement based on nuclear kinase prediction)Immune regulation (expression correlated with immune microenvironment in cancers)Signal transduction (possible, given predicted kinase domains and phosphorylation sites)Other (no confirmed specialized function)
03
Disease associations
Cancer (overexpressed in diverse tumors, correlates with poor prognosis)Diamond-Blackfan anemia 4 (disease association listed in GeneCards)Immune regulation in cancer (modulation of immune microenvironment)Other ("potential biomarker" in cancer suggested in recent research)
04
Biomarkers
Prognostic biomarker in various cancers (based on recent transcriptomic and clinical analyses)
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