Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Chromosome 6 open reading frame 136 (C6orf136)
- Target
- C6orf136
- Molecular classification
- Other (Uncharacterized protein)
01
Overview
Chromosome 6 open reading frame 136 (C6orf136) is a poorly characterized human protein encoded by the C6orf136 gene and contains a conserved DUF2358 domain of unknown function.[1] The gene is broadly expressed, including in heart, intestine, brain, and kidney, and its protein is predicted to localize to the nucleus in humans.[1] The molecular function of C6orf136 remains unelucidated, but studies indicate it may play a role in cancer, especially as a target for FOXM1-induced hypermethylation in head and neck squamous cell carcinoma, and as a prognostic biomarker in bladder cancer through its involvement in self-renewal, migration, and invasion of cancer stem cells.[1][2][3] There are no known drugs targeting C6orf136, and no established mechanisms of action for modulators, reflecting its status as an uncharacterized or research-stage molecular entity rather than a validated therapeutic target.
- Other names
- C6orf136Uncharacterized protein C6orf136DADB-129D20.1MGC15854LOC221545OTTHUMP00000214979CF136_HUMAN
02
Biological functions
Other (Function currently unknown; possible roles in epigenetic regulation, cancer-related processes such as migration and invasion)
03
Disease associations
Cancer (epigenetic regulation and biomarker role in head and neck squamous cell carcinoma and bladder cancer)
04
Biomarkers
Epigenetic biomarker in head and neck squamous cell carcinoma (hypermethylation in FOXM1-induced tumors)[2]Prognostic marker in bladder cancer (differential expression correlated with survival and cancer stem cell differentiation)[1][2]
Beyond the preview
Go deeper on Chromosome 6 open reading frame 136 (C6orf136).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Chromosome 6 open reading frame 136 (C6orf136).