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Chromosome 6 open reading frame 141 (C6orf141)
- Target
- C6orf141
- Molecular classification
- Other (uncharacterized protein; not grouped as kinase, GPCR, transporter, ion channel, transcription factor, or histone modifier)
01
Overview
Chromosome 6 open reading frame 141 (C6orf141) is a small, uncharacterized human protein encoded on chromosome 6p12.3[1][4]. Its expression is broadly detected in normal tissues and is reduced in various cancer types, most notably in oral squamous cell carcinoma, where its low protein levels are associated with advanced tumor stage, nodal involvement, and poor prognosis[2][4]. Functional studies indicate that C6orf141 suppresses tumor proliferation, migration, and invasion in vitro and in vivo[4]. Its biological role may be context-dependent and is the subject of ongoing research in cancer biology, with explorations into its potential as a tumor suppressor and cancer biomarker[2][4]. No role as a canonical drug target, receptor, or enzyme is currently established[1][2][4][5].
- Other names
- C6orf141CF141MGC46457uncharacterized protein C6orf141
02
Mechanism of action
None established for drugs (not a known drug target)
03
Biological functions
Predicted involvement upstream of or within blastocyst hatching (developmental biology)Tumor suppression in oral squamous cell carcinoma: suppresses cancer cell proliferation, migration, invasion, and tumor growthMay affect chemo-responsiveness in triple-negative breast cancer via alternative splicing
04
Disease associations
Cancer (primarily as a candidate tumor suppressor in oral squamous cell carcinoma, potential roles in breast, thyroid, testicular, colon, lung, liver, and other cancers)Prognostic biomarker in oral cancer (and potentially as a biomarker of therapy response in breast cancer)
05
Safety considerations
None established, as it is not yet a therapeutic target; insufficient data
06
Biomarkers
Protein level of C6orf141 in tumor tissue: prognostic for oral squamous cell carcinoma (correlates with disease-specific survival and tumor aggressiveness)Exon‐specific expression associated with chemotherapy response in triple-negative breast cancer
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