Chromosome 6 open reading frame 163 (C6orf163)

Chromosome 6 open reading frame 163 (C6orf163) is a protein-coding gene in humans that encodes an uncharacterized protein of 329 amino acids, with the putative full-length protein having a molecular weight of approximately 38 kDa. Structural predictions indicate the presence of a long alpha helical region and a leucine zipper motif, which are typically associated with DNA-binding and regulatory roles in other proteins, such as transcription factors. C6orf163 is expressed at low levels in most tissues, with highest expression in testes and during early developmental stages (notably at 10 weeks of gestation), and expression declines later in development. It is localized to the nucleus and cytoplasm, suggesting possible regulatory function, but its exact biological activity and physiological role remain to be elucidated. C6orf163 is highly conserved across a wide range of animal species but has no identified paralogs in humans. While a physical interaction with the protein DRC6 (a component of the SCF-type E3 ubiquitin ligase complex involved in ciliary and flagellar function) has been reported, the biological consequence of this interaction is unknown. There are no described therapeutic agents, drug interactions, or known clinical implications for C6orf163 at this time.

Other names

C6orf163Chromosome 6 open reading frame 163Uncharacterized protein C6orf163

None established (no known mechanism of drug action described)