Chromosome 7 open reading frame 25 (C7orf25)

Chromosome 7 open reading frame 25 (C7orf25) encodes a protein known as UPF0415 protein C7orf25, which is a ubiquitously expressed, protein-coding gene found on human chromosome 7[1][2][3]. It belongs to a family of proteins with largely uncharacterized functions and has two conserved isoforms, with high conservation among vertebrates[2][1]. C7orf25/UPF0415 is believed to play a role in ATP-dependent protein degradation within the proteasome pathway and shows multiple phosphorylation sites, suggesting post-translational regulation[2]. It is also proposed to be involved in RNA metabolism and gene expression, potentially through a PIN domain-like superfamily associated with endonuclease activity[4][6]. No evidence currently defines C7orf25 as a classical drug target such as a receptor, enzyme, transporter, or transcription factor, and there are no known drugs or mechanisms of action or notable safety concerns associated with it. C7orf25 has been linked to rare inherited motor neuron diseases but lacks characterized disease-modifying or biomarker roles[3][4].

Other names

UPF0415 protein C7orf25MGC2821expressed sequence AW209491RGD1308147similar to human chromosome 7 open reading frame 25AW209491C17h7orf25