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Chromosome 8 open reading frame 34 (C8orf34)
- Target
- C8orf34
- Molecular classification
- Other (uncharacterized protein; related to cyclic AMP dependent protein kinase regulators)
01
Overview
Chromosome 8 open reading frame 34 is a protein-coding human gene (C8orf34) that encodes a small, monomeric, predominantly unstructured protein. It shows relationship to cyclic AMP dependent protein kinase regulators and is ubiquitously expressed across tissues. Naturally occurring mutations in C8orf34 have been linked to increased susceptibility to severe toxicities (such as diarrhea and neutropenia) in patients treated with chemotherapy. The protein has aliases such as VEST-1 and VEST1, and though it is referenced in disease-association studies (e.g., agammaglobulinemia 7, immunodeficiency 36, colon cancer), its precise biological function and mechanism remain unclear. There are currently no drugs known to target this protein, and it is not considered a validated therapeutic target.
- Other names
- VEST-1VEST1Protein VEST-1Vestibule 1
02
Mechanism of action
Not established
03
Biological functions
Positive regulation (precise biochemical function unknown; related to protein kinase regulation)Ubiquitous expression, possible involvement in cellular response to stress or signalingPotential colon cancer association
04
Disease associations
Reported association with agammaglobulinemia 7Immunodeficiency 36Chemotherapy-related toxicities (increased risk of severe diarrhea and neutropenia with certain alleles)Colon cancer association (based on expression pattern, not established as a direct driver)
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