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Chromosome 8 open reading frame 48 protein (C8orf48)
- Target
- C8orf48
- Molecular classification
- Other, nuclear protein
01
Overview
Chromosome 8 open reading frame 48 protein (C8orf48) is a conserved nuclear protein with predicted nuclear localization signals and no transmembrane or signal peptides. It is involved in regulation of the cell cycle and tumor suppressor proteins and interacts with several transcription factors and proteins associated with cellular growth, proliferation, and inflammatory response. C8orf48 expression is altered in some cancers (breast, thyroid) and disease states (endometriosis), suggesting possible roles in disease etiology or progression, but its molecular function, clinical relevance, or suitability as a therapeutic target remains uncharacterized.
- Other names
- C8orf48FLJ25402chromosome 8 open reading frame 48uncharacterized protein C8orf48
02
Biological functions
Cell cycle controlRegulation of tumor suppressor proteinsInteraction with proteins involved in gene expression, protein secretion, cell proliferation, and inflammatory responses
03
Disease associations
Cancer (breast cancer, papillary thyroid carcinoma: altered expression noted in studies)Endometriosis (differential expression in disease states)
04
Biomarkers
Potential biomarker in certain cancers and endometriosis (based on expression studies, but not validated clinically)
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