Chromosome 9 open reading frame 152 (C9orf152)

Chromosome 9 open reading frame 152 (C9orf152) is an uncharacterized human protein comprising 239 amino acids with a molecular weight of 26.3 kDa[1][5][12]. It is predicted to localize mainly to the nucleus and lacks transmembrane domains[1]. One shorter isoform (194 amino acids) also exists. The protein includes two sumoylation sites and one serine phosphorylation site, with three short alpha-helical regions[1]. C9orf152 is expressed at low-to-moderate levels in various tissues, including bladder, intestine, mammary gland, trachea, lung, liver, prostate, uterus, and brain—particularly in the olfactory bulb[1][6][9]. Gene expression may increase under stress conditions (disease, heat stress)[1]. Evolutionarily, the gene is conserved in mammals, birds, reptiles, and amphibians[1]. Several transcription factors, notably olfactory-related, interact with its promoter region[1]. No molecular family or established classification (such as enzyme, receptor, ion channel, etc.) applies to C9orf152 due to insufficient characterization, and no drug interactions, biomarkers, or therapeutic indications have been reported[3][5][12]. The only attributed molecular role from computational annotation is "protein binding"[3]. There are no notable safety concerns or evidence for its use or evaluation in therapeutics.

Other names

C9orf152bA470J20.2