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Target intelligence / Profile preview
Chromosome Region Maintenance 1 (CRM1)
- Target
- CRM1
- Molecular classification
- Nuclear transport receptor, Other
01
Overview
CRM1, also known as Exportin 1 (XPO1), is the major nuclear export receptor in eukaryotic cells. It mediates the transport of proteins and RNAs from the nucleus to the cytoplasm, a process crucial for cellular homeostasis and gene expression regulation. CRM1 exports proteins with leucine-rich nuclear export signals (NES), ribosomal subunits, U snRNAs, rRNAs, some mRNAs, and other RNPs. Overexpression or mutation of CRM1 is implicated in various cancers, and it is a therapeutic target with inhibitors like selinexor showing promise in cancer treatment.
- Other names
- XPO1Exportin 1XPOIExpIChromosome region maintenance 1 protein homolog
02
Mechanism of action
Inhibition of CRM1 by binding to C528 within the NES cleft, blocking nuclear export
03
Biological functions
Nuclear exportRegulation of gene expressionRibosomal subunit exportCentrosome duplicationSpindle assemblyOther
04
Disease associations
CancerViral infection
05
Safety considerations
Toxicity issues with early inhibitors (e.g., Leptomycin B)Potential safety concerns with SINE compounds
06
Interacting drugs
Leptomycin B
1 more in the full profile.
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