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Target intelligence / Profile preview
Chromosome Region Maintenance Protein 1 (CRM1)
- Target
- CRM1
- Molecular classification
- Karyopherin β, Exportin, Nuclear Export Receptor
01
Overview
Chromosome Region Maintenance Protein 1 (CRM1), also known as Exportin 1 (XPO1), is a highly conserved eukaryotic nuclear export receptor that plays a central role in the transport of proteins and RNAs from the nucleus to the cytoplasm. It mediates the nuclear export of a wide variety of proteins and ribonucleoproteins by recognizing specific amino acid sequences called nuclear export signals (NES) on cargo molecules. Dysregulation or overexpression of CRM1 has been implicated in several cancers, making it an attractive target for cancer therapy.
- Other names
- Exportin 1XPO1
02
Mechanism of action
Small molecule inhibitors block NES-cargo binding, trapping tumor suppressors inside nuclei.
03
Biological functions
Nuclear exportProtein transportRNA transportCentrosome duplicationSpindle assemblyVesicle coat assemblyAutophagyPeroxisome biogenesisCytoskeleton organizationRibosome maturationTranslation controlmRNA degradation
04
Disease associations
Cancer
05
Safety considerations
Dysregulation or overexpression implicated in several cancers.Inhibition may sensitize malignant cells to other therapies.
06
Interacting drugs
Leptomycin B
3 more in the full profile.
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