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Target intelligence / Profile preview
Chromosome transmission fidelity protein 18 homolog (CHTF18)
- Target
- CHTF18
- Molecular classification
- Enzyme, ATPase, Cohesion factor, Replication factor C-like complex subunit
01
Overview
CHTF18 is an evolutionarily conserved protein and an essential subunit of the Replication Factor C-like complex (CTF18-RLC). It coordinates DNA replication, repair, and cohesion establishment during cell division, safeguarding chromosomal integrity. CHTF18 is involved in ATP-dependent loading of PCNA onto DNA, modulation of DNA polymerase activity, and activation of the replication stress response. It plays key roles in chromosome transmission fidelity, especially in germline development and meiosis, and its deregulation is associated with subfertility and cancer due to genome instability. CHTF18 interacts with CTF8, DCC1, RFC2, RFC3, RFC4, RFC5, PCNA, and DNA polymerase POLH, functioning centrally in genome maintenance and chromatid cohesion during S phase and metaphase-anaphase transition.
- Other names
- Chromosome transmission fidelity factor 18CTF18CHL12C16orf41C321D2.4Ctf18chromosome transmission fidelity protein 18 homolog (S. cerevisiae)Some homology with Holliday junction DNA helicase RUVB Like
02
Mechanism of action
Not applicable (no approved drugs target CHTF18 directly); inhibitor/modulator mechanism would theoretically affect DNA replication, chromatid cohesion, or cell cycle checkpoint activation
03
Biological functions
DNA replicationDNA repairSister chromatid cohesionGenome integrity assuranceCell cycle regulationMeiotic recombination
04
Disease associations
Cancer (genome instability)Warsaw Breakage SyndromeRoberts-Sc Phocomelia SyndromeFertility disorders (subfertility, defective spermatogenesis, oocyte development impairments)
05
Safety considerations
Potential for genome instabilityabnormal meiosisinfertilityaneuploidyrisk of impaired DNA repairand cancer development
06
Biomarkers
Delayed DNA double-strand break repair (RAD51 and γH2AX persistence)MLH1 foci reduction in meiosisCHTF18 mutation in tumor genome instability
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