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Chromosome X open reading frame 65 (CXorf65)

Target: CXorf65
Molecular classification: Other (uncharacterized protein)

Overview

Chromosome X open reading frame 65 (CXorf65) encodes a **predominantly nuclear, uncharacterized protein** composed of 183 amino acids with a predicted molecular weight of approximately 21.3 kDa[1][5]. The gene is located at Xq13.1 on the minus strand of the human X chromosome and is expressed at low levels in most tissues, with higher expression in the testis, adrenal, thymus, and bone marrow[1]. Its protein product likely localizes to the nucleus and may play a role in transcriptional regulation via RNA polymerase II, but its exact biological function remains unclear[4][15]. Expression changes have been implicated in fertility disorders (notably azoospermia), cancer prognostics (urothelial and ovarian), and neurological and cardiovascular pathologies, but CXorf65 is not currently recognized as a therapeutic target or as having any drug interactions or well-established safety concerns[1][2][3].

Other names: CXorf65LOC158830Uncharacterized protein CXorf65Hypothetical protein LOC158830A6NEN9 (UniProt accession)

Biological functions

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity[2][4][15]Acts upstream of or within transcription by RNA polymerase II[2][15]Possible role in spermatogenesis and/or testis-specific gene expression[1]

Disease associations

Associated (via differential expression) with azoospermia and impaired spermatogenesis[1]General expression linked to improved prognosis in urothelial and ovarian cancer[1]Hypermethylation reported in temporal lobe epilepsy[1]Downregulation observed in disc herniation, acute coronary syndrome, and presence of TGF-β in eosinophils[1]Possible involvement in severe combined immunodeficiency, X-linked[2][3]

Biomarkers

Differential expression pattern may serve as a biomarker for impaired spermatogenesis and certain cancers[1]

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