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Chromosome X open reading frame 66 (CXorf66)
- Target
- CXorf66
- Molecular classification
- Other (Uncharacterized protein), Type I transmembrane protein (predicted), Mammalian-specific protein family
01
Overview
Chromosome X open reading frame 66 (CXorf66, SGPX) encodes an uncharacterized human protein predicted to be a type I transmembrane glycoprotein. It is serine- and lysine-rich, with multiple predicted post-translational modifications (signal peptide, glycosylation, phosphorylation, sumoylation). CXorf66 is primarily expressed in testis and serum, and has been upregulated in several cancers (brain, lung, and leukemias), with downregulated expression seen in liver and prostate cancers. It is genomically located at Xq27.1, in proximity to SOX3, and may be implicated by association in aspects of sex determination and non-syndromic X-linked intellectual disability. CXorf66 has no confirmed biological function or interacting drugs and is not currently considered a therapeutic or pharmacological target
- Other names
- CXorf66SGPXChromosome X open reading frame 66RP11-35F15.2Secreted glycoprotein, X-linked
02
Mechanism of action
None established (no drugs identified)
03
Biological functions
Other (Function unknown)Possible role in sex determination regulation (via genomic deletions/association near SOX3)Possible biomarker function (cancer)
04
Disease associations
Cancer (potential biomarker, differential expression in brain and lung cancers, leukemias, down-regulated in liver and prostate cancer)Intellectual disability (association reported)Other (Pasteurellosis)Potential involvement in infertility/sex differentiation (case reported with region deletion)
05
Safety considerations
None reported (no therapeutic or drug associations)
06
Interacting drugs
None known or reported
07
Biomarkers
CXorf66/SGPX itself proposed as a candidate biomarker for cancer, particularly in brain and lung cancers, and possibly for sex development/infertilityNo established clinical biomarker utility
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