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Target intelligence / Profile preview
Chronic Inflammation Pathways
- Molecular classification
- Signaling pathway, Immune pathway
01
Overview
Chronic Inflammation Pathways refer to the complex network of molecular and cellular mechanisms that sustain long-term inflammatory responses. These pathways involve a multitude of cytokines, transcription factors, pattern recognition receptors, and immune cell types, leading to tissue damage and contributing to the pathogenesis of various chronic diseases.
02
Mechanism of action
Varies depending on the specific drug target within the pathway. Examples include blocking cytokine signaling, depleting immune cells, or modulating receptor activity.
03
Biological functions
Immune responseInflammationTissue repairSignal transduction
04
Disease associations
Autoimmune diseasesRheumatoid ArthritisInflammatory Bowel DiseaseAsthmaCardiovascular DiseaseCancerChronic Inflammatory Diseases
05
Safety considerations
Increased risk of infectionImmunosuppressionOpportunistic infectionsCardiovascular side effectsGastrointestinal side effects
06
Interacting drugs
TNF-alpha inhibitors
4 more in the full profile.
07
Biomarkers
TNF-alpha levelsIL-6 levelsCRP (C-reactive protein)ESR (Erythrocyte Sedimentation Rate)Specific autoantibodies
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