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Target intelligence / Profile preview
Chronic lymphocytic leukemia up-regulated 1 (CLLU1)
- Target
- CLLU1
- Molecular classification
- lncRNA (long non-coding RNA), Other (putative protein-coding gene, but current evidence classifies as lncRNA)
01
Overview
Chronic lymphocytic leukemia up-regulated 1 (CLLU1) is a human gene initially thought to encode a protein, but current evidence classifies it as a long non-coding RNA (lncRNA) gene. CLLU1 is specifically and highly upregulated in chronic lymphocytic leukemia cells and is not expressed in other tissues or hematological malignancies. Its function remains unknown: the gene is human-specific, poorly conserved across species, and protein expression from CLLU1 has not been convincingly detected. CLLU1 expression is stable within CLL cell clones and is used as a robust marker for prognostic and diagnostic classification of CLL patients, but is not targeted by any therapies nor recognized as a receptor, enzyme, or other classic drug target.
- Other names
- Chronic lymphocytic leukemia up-regulated protein 1CLLU1CLLU1_HUMAN (UniProtKB)GC12U900504 (GeneCards ID)ENSG00000257127 (Ensembl)NCBI Gene: 574028
02
Biological functions
Prognostic biomarker in chronic lymphocytic leukemia (CLL)Diagnostic biomarker in CLLOther (no definitive biological molecular function described)
03
Disease associations
Cancer (specifically Chronic lymphocytic leukemia)Other leukemia subtypes (minor/indirect potential but reported as CLL-specific)
04
Biomarkers
CLLU1 expression level by QRT-PCR as a stable prognostic biomarker in CLLUsed for patient risk stratification in CLL
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