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Target intelligence / Profile preview
Chronic total occlusion of the coronary artery (CTO)
- Target
- CTO
- Molecular classification
- Other
01
Overview
Chronic total occlusion (CTO) refers to a complete blockage (100% occlusion) of a coronary artery persisting for three months or longer, usually caused by atherosclerotic plaque formation. CTO is a severe manifestation of coronary artery disease and commonly results in symptoms of angina, shortness of breath, and increased risk for myocardial infarction. Treatments focus on restoring blood flow, often through percutaneous coronary intervention (PCI) with stenting or coronary artery bypass grafting (CABG). CTO is assessed by angiography and is not a protein, gene, or molecular receptor but a clinical syndrome caused by physical obstruction in a blood vessel.
- Other names
- Chronic total occlusioncoronary artery occlusioncoronary occlusionCTO
02
Biological functions
Other
03
Disease associations
Cardiovascular diseaseCoronary artery diseaseIschemic heart diseaseMyocardial infarction
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