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Target intelligence / Profile preview
Churchill domain containing protein 1 (CHURC1)
- Target
- CHURC1
- Molecular classification
- Transcription factor, Developmental protein
01
Overview
Churchill domain containing protein 1 (CHURC1) is a zinc finger-containing transcriptional activator that mediates fibroblast growth factor (FGF) signaling during neural development and has a role in regulating cell movement. It does not bind DNA directly and is believed to function via protein-protein interactions within the cell nucleus, contributing to neural tissue patterning and possibly other developmental processes[1][6][8]. There is no current evidence supporting its use as a direct therapeutic target, nor are there known drugs, clinical biomarkers, or safety challenges related to direct targeting of CHURC1 in medicine.
- Other names
- Protein ChurchillC14orf52CHCHMy015FLJ33064chch
02
Biological functions
Transcriptional activationMediates fibroblast growth factor (FGF) signaling during neural developmentRegulation of cell movement
03
Disease associations
Potentially implicated in developmental diseases (listed associations: Polycystic kidney disease 1, Contractural arachnodactyly, congenital), but no strong evidence as a driver or biomarker in common human disease[1]
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