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Target intelligence / Profile preview
Chymase
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Chymase is a chymotrypsin-like serine protease predominantly found in mast cells. It plays a key role in the conversion of angiotensin I to angiotensin II, tissue remodeling, and inflammation. Due to its involvement in cardiovascular diseases and fibrosis, it is a therapeutic target for developing inhibitors.
02
Mechanism of action
Chymase inhibitors block the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and promoting vasodilation. They can also prevent the degradation of extracellular matrix components, reducing fibrosis and inflammation.
03
Biological functions
Angiotensin I to Angiotensin II conversionTissue remodelingExtracellular matrix protein cleavageActivation of matrix metalloproteinases (MMPs)Inflammation mediation
04
Disease associations
HypertensionHeart failureAsthmaFibrosisCardiovascular diseaseAtopic dermatitisKeloids
05
Safety considerations
Potential for off-target effects due to serine protease inhibitionPossible interference with normal tissue repair processes
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