Chymase 1 (CMA1)

Chymase 1 is a serine protease enzyme encoded by the *CMA1* gene, primarily expressed in mast cells, and plays a central role in the local generation of angiotensin II from angiotensin I, independent of angiotensin-converting enzyme (ACE)[1][2][3][4]. It is involved in numerous biological processes including degradation of the extracellular matrix, regulation of submucosal gland secretion, activation of TGF-β, and modulation of inflammatory cytokines[1][2][3][6]. Through these actions, chymase 1 contributes to tissue remodeling, blood pressure regulation, and the pathogenesis of various diseases, particularly fibrosis and cardiovascular disease. Because of its role in converting angiotensin I to angiotensin II, chymase 1 has emerged as a therapeutic target, especially in cardiovascular and fibrotic diseases, though approved drugs specifically targeting chymase are still under development and not widely available for clinical use[2][4][6].

Other names

ChymaseCYHCYMAlpha-chymaseMast cell protease IMCT1mast cell chymasechymase 1 preproprotein (various transcripts)heart chymase

Inhibition of chymase enzymatic activity, thereby blocking conversion of angiotensin I to angiotensin II Inhibition of extracellular matrix degradation Prevention of TGF-β and matrix metalloproteinase activation Attenuation of local inflammatory/fibrotic processes