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Target intelligence / Profile preview
Chymotrypsin-like elastase family member 2B (CELA2B)
- Target
- CELA2B
- Molecular classification
- Enzyme, Serine protease, Peptidase
01
Overview
Chymotrypsin-like elastase family member 2B (CELA2B) is a human enzyme encoded by the CELA2B gene. It belongs to the serine protease family, specifically one of six closely related elastases found in humans. CELA2B is synthesized in the pancreas as a zymogen (inactive precursor) and is secreted into the duodenum where it contributes to protein digestion by hydrolyzing peptide bonds after specific hydrophobic amino acids, especially leucine, methionine, and phenylalanine. This enzyme is structurally similar to other human elastases, such as elastase 2A and 3A, and is classified under EC 3.4.21.71. Unlike some other elastases, no specific small molecule inhibitors or drugs are currently known to target CELA2B, and its direct clinical or diagnostic utility as a biomarker or drug target is currently limited. There are some disease associations in genetic studies, but a clear mechanistic role has yet to be established for these[1][2][4][5].
- Other names
- Elastase 2BPancreatic elastase IIBELA2BRP11-265F14.2Chymotrypsin-like elastase family, member 2B
02
Biological functions
Protein hydrolysis/proteolysisDigestion of dietary proteinsCleavage of peptide bonds after specific amino acids (leucine, methionine, phenylalanine)
03
Disease associations
Other (potent association reported with rare diseases such as Peyronie disease and Potocki-Lupski syndrome, but not established as a primary disease driver)
04
Safety considerations
Potential overlap or redundancy with other pancreatic elastases may complicate specific therapeutic targeting
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