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Target intelligence / Profile preview
Chymotrypsin-like elastase family member 3A (CELA3A)
- Target
- CELA3A
- Molecular classification
- Enzyme, Serine protease
01
Overview
Chymotrypsin-like elastase family member 3A (CELA3A) is a serine protease enzyme produced by the pancreas and secreted into the intestine in an inactive (zymogen) form, where it aids in digestion by preferentially cleaving peptide bonds after alanine residues. It shows little true elastolytic activity compared to other elastases. CELA3A has an important role in the intestinal digestion of dietary proteins and may also facilitate the intestinal transport and metabolism of cholesterol. It belongs to the peptidase S1 family of serine endopeptidases. Clinically, its activity is measured in fecal assays (as "fecal elastase-1") to assess pancreatic exocrine function, but it is not a common direct therapeutic target[1][2][9].
- Other names
- ELA3AELA3elastase IIIAelastase-3Aprotease Eelastase 1chymotrypsin like elastase 3Aelastase 3A, pancreatic
02
Biological functions
Proteolysis (protein digestion)Intestinal protein and peptide digestionIntestinal transport and metabolism of cholesterol[1][2][9]
03
Disease associations
Other (mainly digestive dysfunction if mutated or deficient)no clear association with cancer, inflammation, or other major diseases at present
04
Safety considerations
Potential for off-target effects if inhibited, such as impaired protein digestion or altered nutrient absorption, but this is theoretical (there are no drugs that directly inhibit CELA3A clinically)
05
Biomarkers
Fecal elastase-1 (measured to assess exocrine pancreatic function, but most commercial assays do not distinguish CELA3A from similar elastases)[2]
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