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Target intelligence / Profile preview
Chymotrypsin-like Proteasome Activity (n/a)
- Target
- n/a
- Molecular classification
- Enzyme, Protease, Proteasome subunit
01
Overview
Chymotrypsin-like proteasome activity refers to the proteolytic function of the β5 subunit of the 20S proteasome core particle, responsible for cleaving peptide bonds after large hydrophobic amino acid residues. It plays a critical role in protein degradation, immune function, and cellular homeostasis, making it a therapeutic target in diseases like cancer. Assays typically measure this activity using fluorogenic substrates like Suc-Leu-Leu-Val-Tyr-AMC.
- Other names
- Proteasome chymotrypsin-like activityCT-L activity of proteasomeβ5 proteasome activity
02
Mechanism of action
Inhibition of chymotrypsin-like proteolytic activity of the proteasome β5 subunit.
03
Biological functions
Protein degradationRegulation of protein turnoverAntigen presentationCell cycle regulationApoptosisImmune response
04
Disease associations
CancerInflammationNeurodegenerative diseases
05
Safety considerations
ImmunosuppressionPeripheral neuropathyCardiotoxicity
06
Interacting drugs
Bortezomib
2 more in the full profile.
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