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Target intelligence / Profile preview
Cilia- and flagella-associated protein 107 (CFAP107)
- Target
- CFAP107
- Molecular classification
- Other (Microtubule-associated protein, axonemal component)
01
Overview
Cilia- and flagella-associated protein 107 (CFAP107) is a microtubule inner protein (MIP) localized to the axonemal doublet microtubules of motile cilia, where it contributes to the structural integrity and function necessary for ciliary and flagellar beating[5][8]. It is critical for the movement of flagellated sperm and the proper motility of cilia[6][7], but is not currently recognized as a therapeutic target, nor are any drugs reported to interact with it. The gene is located on chromosome 1 in humans and is highly conserved across species, indicating a fundamental role in cellular motility mechanisms[1][3][6]. There are no established links between CFAP107 and specific diseases, interacting drugs, recognized biomarkers, or notable therapeutic safety concerns as of current knowledge.
- Other names
- C1orf158MGC35194protein CFAP107uncharacterized protein C1orf158cilia- and flagella-associated protein 107CFAP1071700012P22Rik (mouse orthologue)
02
Biological functions
Motile cilia beatingFlagellated sperm motility
03
Disease associations
Other (potential implication in ciliary dysfunction or motility disorders, no direct disease association established)
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