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Target intelligence / Profile preview
Cilia- and flagella-associated protein 141 (CFAP141)
- Target
- CFAP141
- Molecular classification
- Other (Microtubule inner protein, structural protein)
01
Overview
Cilia- and flagella-associated protein 141 (CFAP141) is a structural protein localized to the axonemal outer junctions of motile cilia and flagella in humans[1][2]. It is part of the microtubule inner proteins (MIPs) group and contains a conserved ELLEn module at its N-terminus. This module facilitates binding between microtubule A and B tubules, enabling the assembly and structural cohesion of the ciliary outer doublet. CFAP141 shares evolutionary and structural homology with CFAP53 and trichoplein (TCHP). It interacts with other MIPs such as CFAP53 and the centrosomal protein NME7 to support ciliary architecture, but there is no current evidence of direct pharmacological targeting, disease biomarker role, or clinical safety concerns related to this protein[1][2].
- Other names
- CFAP141C1orf189cilia- and flagella-associated protein 141protein CFAP141uncharacterized protein C1orf189
02
Biological functions
Ciliary and flagellar architectureMicrotubule bindingAssembly of cilia outer doubletStructural support within motile cilia and flagella
03
Disease associations
Other (no documented direct involvement in major human diseases as of current reports; mutations in some CFAP family proteins are linked to ciliopathies, but specific disease association for CFAP141 is not confirmed)
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