Cilia- and flagella-associated protein 161 (CFAP161)

Cilia- and flagella-associated protein 161 (CFAP161) is a conserved protein found in the axonemal microtubules of motile cilia and flagella, localizing mainly to the inner part of doublet microtubules in the ciliary axoneme[1][7][2]. It is regulated by the cilia-specific transcription factor FOXJ1 and is required for correct assembly and function of motile cilia in some evolutionary contexts[1][2][7]. Experimental disruption of CFAP161 in model organisms such as mouse and Xenopus surprisingly did not result in obvious motile cilia phenotypes, although some gene expression changes associated with ciliary structure and function were observed[1]. In humans, CFAP161 maps to chromosome 15q and has been considered a possible candidate gene in inherited disorders of motile cilia such as primary ciliary dyskinesia and Kartagener syndrome, though definitive pathogenic roles are not established[1][2]. CFAP161 is not currently regarded as a therapeutic target (enzyme, receptor, or transporter) and there are no known drugs or clinical biomarker applications associated with it[2][7].

Other names

C15orf26FLJ38615CF161Cilia and flagella associated protein 161