Cilia- and flagella-associated protein 263 (CFAP263)

Cilia- and flagella-associated protein 263 (CFAP263), previously known as "coiled-coil domain containing 113" (CCDC113), is a protein predominantly localized to centriolar satellites and the ciliary basal body, where it contributes to the assembly and function of cilia[1][5]. It acts as a component of a protein complex that regulates ciliary beating by connecting structural elements critical for normal cilium motility and maintenance, including the radial spoke 3, inner dynein arm, and nexin-dynein regulatory complex[1][5]. Mutations in CFAP263 have been linked to human diseases such as retinitis pigmentosa and optic atrophy, indicating its importance in sensory and potentially neural tissues[1]. CFAP263 is not a typical receptor, enzyme, transporter, or common therapeutic target, but rather serves a structural role in cilia and flagella. There is some evidence suggesting a role in cancer, but its direct therapeutic targeting or use in biomarker applications remains unsupported by current evidence[7].

Other names

CCDC113HSPC065DKFZp434N1418coiled-coil domain containing 113coiled-coil domain-containing protein 113