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Target intelligence / Profile preview
Cilia- and flagella-associated protein 58 (CFAP58)
- Target
- CFAP58
- Molecular classification
- Other (structural protein associated with cilia and flagella)
01
Overview
Cilia- and flagella-associated protein 58 (CFAP58) is a structural protein essential for the assembly and organization of motile cilia and the sperm flagellar axoneme. It is enriched in testicular tissue, localizes to the sperm midpiece, and is required for the elongation of the primary cilium and sperm midpiece, potentially by modulating the Notch signaling pathway. CFAP58 is crucial for cellular projections like cilia and flagella, impacting processes such as sperm motility, and its dysfunction is implicated in male infertility and may contribute to diseases related to ciliary and flagellar abnormalities.
- Other names
- C10orf80CCDC147FLJ35908bA554P13.1Coiled-coil domain-containing protein 147SPGF49bA127L20.4bA127L20.5
02
Biological functions
Cilia assemblyFlagella assemblySperm axoneme organizationProtein localization to motile ciliumSperm mitochondrial sheath assemblyModulation of Notch signaling pathway
03
Disease associations
Spermatogenic failure (male infertility)Other (potential role in ciliopathies and flagellar abnormalities)
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