Cilia- and flagella-associated protein 65 (CFAP65)

Cilia- and flagella-associated protein 65 (CFAP65) is a structural protein containing coiled-coil domains, primarily involved in the formation and functional integrity of cilia and flagella. It plays a critical role in sperm flagellar structure and motility, with mutations in the gene associated with defects such as immotile sperm and forms of male infertility. The chicken ortholog is linked to morphological changes in bird combs due to chromosome inversion, demonstrating its impact on cellular organization and motility. There is no evidence supporting direct drug targeting of CFAP65 for therapeutic purposes or its use as a biomarker or safety concern in clinical practice.

Other names

CCDC108DKFZp434O0527MGC35338Coiled-coil domain-containing protein 108SPGF40cilia and flagella associated protein 65coiled-coil domain containing 108