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Target intelligence / Profile preview
Cilia- and flagella-associated protein 68 (CFAP68)
- Target
- CFAP68
- Molecular classification
- Other (Microtubule inner protein; structural axonemal protein)
01
Overview
CFAP68 is a microtubule inner protein (MIP) that localizes to the seam of microtubule doublets within motile cilia and flagella, where it contributes to the structural integrity and organization of the axoneme[3][2]. In human cells, its localization is at the distal region of motile cilia, and it is essential for proper microtubule architecture, affecting the mechanical properties and regulation of ciliary and flagellar beating[2]. It is highly conserved in ciliated organisms and is critical for the correct motility and assembly of sperm flagella and other motile cilia[5][2]. If structural or functional defects arise in CFAP68, they may impact sperm motility and possibly contribute to ciliopathies, but it is not an established biomarker, drug target, or therapeutic receptor based on current evidence[5][1].
- Other names
- CFAP68C11orf1FLJ23499UPF0686 protein C11orf1cilia- and flagella-associated protein 68
02
Mechanism of action
null
03
Biological functions
Sperm motilityMotile cilium/flagellum architectureAxoneme structural stabilization
04
Disease associations
Other (Potential roles in ciliopathies or motility disorders due to architectural defects; no established links to major human diseases)
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