Cilia- and flagella-associated protein 70 (CFAP70)

Cilia- and flagella-associated protein 70 (CFAP70) is a structural protein enriched in motile cilia and sperm flagella, characterized by multiple tetratricopeptide repeat (TPR) domains that mediate protein–protein interactions[1][2]. CFAP70 localizes strongly to the axonemal cytoskeleton in cilia, where it acts as a regulatory component for the outer dynein arm (ODA) machinery, influencing the motility of cilia and flagella[1][2]. Knockdown or genetic disruption of CFAP70 leads to impaired ciliogenesis, decreased ciliary beating, disruption of axonemal structure, male infertility (due to flagellar biogenesis defects in spermatids), and hydrocephalus due to functional loss in brain cilia[2]. It interacts with the flagellar assembly machinery and stabilizes partner proteins such as QRICH2[2]. While not a classical drug target, pathogenic mutations in CFAP70 serve as important genetic markers for the diagnosis of certain syndromes of male infertility and ciliary disease[2].

Other names

CFAP70TTC18TPR repeat protein 18FLJ25765Tetratricopeptide repeat protein 18SPGF41cilia- and flagella-associated protein 70Tetratricopeptide repeat domain 18Tetratricopeptide repeat-containing protein (LOC118491)