Cilia- and flagella-associated protein 90 (CFAP90)

Cilia- and flagella-associated protein 90 (CFAP90) is a human protein encoded by the CFAP90 gene (previously known as C5orf49, LOC134121), primarily localized within the axoneme and ciliary basal body of motile cilia and flagella[3][5][7]. It functions as a microtubule inner protein (MIP) critical for the integrity and proper beating of motile cilia, contributing to processes such as sperm motility and possibly the movement of fluid across ciliated epithelia[3][2][7]. Mutations in CFAP90 have been associated with disorders such as lacrimal duct obstruction and cone-rod dystrophy 18, highlighting its role in ciliary structure and function[3]. Currently, CFAP90 is not recognized as a druggable therapeutic target or used as a biomarker. No drug interactions or clinical mechanisms are reported, and it is best classified as an essential component of the molecular machinery of the ciliary axoneme, with a primary structural and motility role rather than as an enzyme, transporter, receptor, or transcription factor[3][7].

Other names

CFAP90C5orf49LOC134121cilia and flagella associated protein 90uncharacterized protein C5orf49