Target intelligence / Profile preview

Cilia- and flagella-associated protein HOATZ (HOATZ)

Target: HOATZ
Molecular classification: Other

Overview

Cilia- and flagella-associated protein HOATZ (HOATZ) is a vertebrate-specific, intrinsically disordered protein required for motile cilia and flagella formation, mediating ENO4 maturation and interacting with heat shock proteins; its deficiency leads to hydrocephalus and infertility in animal models, but it is not a current therapeutic target.

Other names: C11orf88HOATZINFLJ46266UPF0722 protein C11orf88protein Hoatzhypothetical gene supported by BC039505

Biological functions

Motile ciliogenesisFlagellar genesisAxoneme assemblyENO4 maturationSpermatogenesisStress regulation in ciliated cells

Disease associations

Male infertilityHydrocephalusOther (potential ciliopathies)

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