Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cilia and flagella associated protein 276 (CFAP276)
- Target
- CFAP276
- Molecular classification
- Other (Microtubule-associated protein, axonemal protein, microtubule inner protein)
01
Overview
Cilia and flagella associated protein 276 (CFAP276) is a microtubule inner protein (MIP) that is part of the dynein-decorated doublet microtubules in the cilia axoneme, a core structural component of motile cilia and flagella[3][5]. CFAP276 is predicted to be involved in regulating flagellated sperm motility and is localized within axonemal microtubules, which are critical for cilia function[3][4][5]. It may also contribute to the maintenance of myelin-axon integrity and influence intracellular calcium homeostasis, though these are suggested by functional similarity rather than confirmed direct activity in humans[3][5]. CFAP276 is not currently recognized as a direct therapeutic target (receptor, enzyme, transporter, etc.), and there are no known drugs that specifically interact with this protein[3][5]. Mutations or variations in CFAP276 have been associated with Charcot-Marie-Tooth disease, implicating a potential, though indirect, disease association[3].
- Other names
- C1orf194 (previous symbol)CF276_HUMAN (UniProt)Q5T5A4 (UniProt accession)ENSG00000179902 (Ensembl)
02
Biological functions
Flagellated sperm motilityMaintenance of motile cilia beatingMay play a role in myelin-axon integrity (by similarity)May affect intracellular Ca(2+) homeostasis
03
Disease associations
Charcot-Marie-Tooth diseasePeripheral nervous system disease (possible association; not a primary target)
Beyond the preview
Go deeper on Cilia and flagella associated protein 276 (CFAP276).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cilia and flagella associated protein 276 (CFAP276).