Cilia and flagella associated protein 53 (CFAP53)

Cilia and flagella associated protein 53 (CFAP53; also known as coiled-coil domain containing 11, CCDC11) is a conserved structural and regulatory protein essential for the assembly and motility of motile cilia and flagella in mammals[1][3][4][5][6]. CFAP53 localizes to centriolar satellites, the base, and the axoneme of cilia and flagella, where it stabilizes and promotes the transport and docking of dynein motor proteins and other cargoes[1][3]. Its loss disrupts ciliary/flagellar biogenesis, results in impaired sperm motility and morphology, and underlies developmental abnormalities such as visceral heterotaxy and primary ciliary dyskinesia, indicating a key role in left-right axis patterning during embryogenesis[4][5][6]. Although critical for cellular and developmental function, it is not a direct pharmacological target and currently lacks pathways for small-molecule modulation or therapeutic intervention.

Other names

CFAP53CCDC11 (Coiled-coil domain containing 11)HTX6FLJ32743cilia and flagella associated protein 53coiled-coil domain-containing protein 11

Not applicable — no drugs are known to act directly on CFAP53; its functional mechanism is structural/regulatory: - Cargo stabilization and transport to cilia/flagella via microtubule-associated mechanisms and interaction with molecular motors and dynein complexes[1][3].