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Target intelligence / Profile preview
Cilia and flagella associated protein 91 (CFAP91)
- Target
- CFAP91
- Molecular classification
- Other (protein coding gene, axonemal/ciliary structural/regulatory protein)
01
Overview
Cilia and flagella associated protein 91 (CFAP91) is a structural and regulatory protein involved in the assembly of the axonemal central apparatus, especially in motile cilia and sperm flagella. It is important for cilium motility and sperm flagellum organization, playing a key role in spermatogenesis. Genetic variants of CFAP91 are implicated in specific forms of male infertility, particularly related to defective sperm motility and morphology[1][2][3][5][7].
- Other names
- MYCBP/AMY-1-Associated, Testis Expressed 1MYCBP associated and testis expressed 1MYCBP-Associated, Testis Expressed 1Spermatogenesis associated 26MYCBP-binding proteinProtein MAATS1Chromosome 3 open reading frame 15AAT1-alphaSPGF51
02
Biological functions
Axonemal central apparatus assemblyCilium motility regulationSperm flagellum axonemal organizationSpermatogenesis
03
Disease associations
Male infertility (associated with spermatogenic failure 51 and male infertility with teratozoospermia due to single gene mutation)
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