Cilia and flagella associated protein 97 domain containing 1 (CFAP97D1)

CFAP97D1 (cilia and flagella associated protein 97 domain containing 1) is a highly conserved testis-enriched protein that belongs to the CFAP97 family, present in both humans and other mammals[1]. It is exclusively expressed in the testis, where it plays a vital role during spermatogenesis, starting from the late diplotene/diakinesis stage[1]. Genetic loss of CFAP97D1 in mouse models results in severe sperm motility defects (asthenozoospermia) and male subfertility caused by abnormal axonemal structure, notably frequent loss of axonemal microtubule doublets in mature sperm[1]. CFAP97D1’s fundamental function is the maintenance of sperm flagellar axoneme integrity, making it essential for sperm motility and effective fertilization in vivo. Impaired function is associated with phenotypes resembling MMAF syndrome, though its implication in human infertility and as a clinical biomarker or drug target remains to be elucidated[1].

Other names

Sperm axonemal maintenance protein CFAP97D1C17orf105CFAP97 domain-containing protein 1uncharacterized protein C17orf105CFAP97D1