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Ciliary-associated calcium-binding coiled-coil protein 1 (CABCOCO1)
- Target
- CABCOCO1
- Molecular classification
- Calcium-binding protein, Coiled-coil domain-containing protein, CLAMP motif-containing protein, Other (not classified as receptor, enzyme, transporter, ion channel, transcription factor, or histone modifier)
01
Overview
Ciliary-associated calcium-binding coiled-coil protein 1 (CABCOCO1) is a protein characterized by the presence of a coiled-coil domain and a CLAMP motif, enabling calcium ion binding[1][2][3]. It localizes to the centrosome and cytoplasm during spermatogenesis and relocates to the sperm flagellum, where it may regulate flagellar movement and function. CABCOCO1 is implicated in processes related to sperm motility and flagellum assembly in mammals, with known association to certain disorders of ciliary function, such as cone-rod dystrophy 10 and primary ciliary dyskinesia[1][3][4][7][8]. There is no evidence supporting its role as a therapeutic target, nor are there any known drug interactions, mechanisms of action, or safety concerns specific to CABCOCO1.
- Other names
- CABCOCO1Ciliary-associated calcium-binding coiled-coil protein 1C10orf107bA63A2.1Em:AC022398.2MGC44593CBCO1ARIELARID5B-inducing enhancer associated long noncoding RNAuncharacterized protein C10orf107
02
Mechanism of action
None documented. No mechanism of drug action reported for this molecule
03
Biological functions
Calcium ion bindingSperm flagellum assemblyControl of sperm flagellar movementLocalization to centrosome and cytoplasm in spermatogenic cells
04
Disease associations
Associated with Cone-rod dystrophy 10Associated with Primary ciliary dyskinesiaOther (no established role in major therapeutic areas like cancer, cardiovascular disease, etc.)
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