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Target intelligence / Profile preview
Ciliary microtubule-associated protein 3 (CIMAP3)
- Target
- CIMAP3
- Molecular classification
- Other, Microtubule-associated protein, Cytoskeletal protein
01
Overview
Ciliary microtubule-associated protein 3 (CIMAP3) is a cytoskeletal protein that participates in the process of primary cilia disassembly. It is specifically required for controlling cilia retraction and for the liberation and duplication of the basal body/centrosome, likely by stimulating AURKA (Aurora kinase A) activity at the basal body in a cell cycle-dependent manner. CIMAP3 is predicted to localize to the ciliary basal body and the trans-Golgi network, and has protein binding and enzyme binding activities. Genetic mutations in CIMAP3 are linked to human ciliopathies and disordered developmental syndromes characterized by defects in cilia-mediated signaling and structure[1][3][5][7].
- Other names
- C1orf88PIFOFLJ23853pitchforkProtein pitchforkciliary microtubule-associated protein 3CIMAP3
02
Biological functions
Cilia disassemblyCilia retractionLiberation and duplication of basal body/centrosomeCytoskeletal protein bindingEnzyme bindingPositive regulation of kinase activity
03
Disease associations
CiliopathiesOrofaciodigital syndrome IChondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmiaAlstrom syndrome
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