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Target intelligence / Profile preview
Ciliary microtubule inner protein 2B (CIMIP2B)
- Target
- CIMIP2B
- Molecular classification
- Other (Microtubule inner protein; structural axoneme protein)
01
Overview
Ciliary microtubule inner protein 2B (CIMIP2B) is a microtubule inner protein (MIP) localized to the axonemal doublet microtubules of motile cilia and flagella. It functions as a structural element required for ciliary beating and sperm motility, contributing to the integrity and dynamic motion of these cellular appendages. CIMIP2B is part of the broader family of MIPs, which act predominantly as structural adaptors or scaffolds within the microtubule lumen, rather than enzymes or receptors. In humans, disease associations include certain neurodevelopmental disorders and lipomatosis, but its direct involvement as a drug target, biomarker, or safety concern in therapeutics is not established.
- Other names
- FAM166Bfamily with sequence similarity 166 member Bprotein FAM166BCIMIP2B4833436C18Rik (mouse)
02
Biological functions
Motile cilia beatingFlagellated sperm motilityAxonemal microtubule structural integrity
03
Disease associations
Neurodevelopmental disorder with eye movement abnormalities and ataxiaMultiple symmetric lipomatosis
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