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Target intelligence / Profile preview
Ciliary microtubule inner protein 2C (CIMIP2C)
- Target
- CIMIP2C
- Molecular classification
- Other (Microtubule-associated structural protein, specifically the inner protein of ciliary/flagellar axonemal microtubules[3])
01
Overview
Ciliary microtubule inner protein 2C (CIMIP2C) is a protein localized to the axonemal microtubules of motile cilia, forming part of the dynein-decorated doublet microtubules essential for ciliary beating[3]. It binds intra-tubulin interfaces and is predicted to be involved in flagellated sperm motility. Mutations or dysfunction are theoretically relevant in disorders of ciliary motility, but specific disease associations or roles have not been established. The gene uses several aliases and is catalogued as a protein coding gene without known signaling or enzymatic function. It does not serve as a known drug target, nor are there disease biomarkers or safety concerns linked to pharmacological interventions[3].
- Other names
- CIMIP2CC2orf70FAM166CLOC339778Hypothetical protein LOC339778UPF0573 protein C2orf70Family with sequence similarity 166 member CProtein FAM166CCiliary microtubule inner protein 2C
02
Mechanism of action
Null. No drugs target CIMIP2C, so no mechanism of pharmacological action is described[3].
03
Biological functions
Motile cilia beating (it is required for the beating of motile cilia as a structural component of the axoneme)[3]Flagellated sperm motility (predicted)[3]
04
Disease associations
Other (No direct disease associations found as of this writing. Its structural role implies possible relevance in ciliary dyskinesia or motility disorders if mutated, but there is no evidence of involvement in cancer, inflammation, neurodegeneration, cardiovascular disease, or infection[3])
05
Safety considerations
None specifically associated with therapeutic targeting, as it is not considered a therapeutic target[3].
06
Interacting drugs
None found. No drugs are reported to interact with CIMIP2C, and it is not targeted by any approved or investigational agents[3].
07
Biomarkers
None identified as relevant for CIMIP2C in patient selection or efficacy monitoring[3].
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