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Target intelligence / Profile preview
Ciliary Neurotrophic Factor Receptor (CNTFR)
- Target
- CNTFR
- Molecular classification
- Type I cytokine receptor
01
Overview
The ciliary neurotrophic factor receptor (CNTFR) is a type I cytokine receptor that forms a complex with gp130 and LIFRβ upon binding to ciliary neurotrophic factor (CNTF). This complex activates intracellular signaling cascades, promoting neuronal survival, differentiation, and regulating apoptosis. The receptor is attached to the cell membrane via a glycophosphatidylinositol (GPI) linkage.
02
Mechanism of action
CNTF binds to CNTFRα, recruiting gp130 and LIFRβ to form a signaling complex, triggering intracellular pathways.
03
Biological functions
Supports neuron survivalPromotes neurotransmitter synthesisPromotes neurite outgrowthRegulates cell activity and apoptosisSignal transduction
04
Disease associations
Neuromuscular regenerationNeurodegenerative disease
05
Safety considerations
Potential for acting via multiple related receptors at high concentrations
06
Interacting drugs
Ciliary neurotrophic factor (CNTF)
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