Ciliary rootlet coiled-coil protein 2 (CROCC2)

CROCC2 (Ciliary rootlet coiled-coil protein 2) is a human-specific protein of 111 amino acids arising from partial duplication of the rootletin (CROCC) gene. It is primarily expressed during human brain development, especially in the fetal cortex, and not in other primate species. CROCC2 regulates ciliary length and dynamics by interacting with the ciliary trafficking protein IFT20, leading to altered neurogenesis through increased mTOR signaling and expansion of basal cortical progenitors. Its function highlights a species-specific role in the evolution of human cortical development. No direct therapeutic applications or disease associations are documented, though its biology may inform future research into neurodevelopmental disorders[3][5][6].

Other names

Rootletin family member 2Ciliary rootlet coiled-coil protein 2CROCC2 genePutative ciliary rootlet coiled-coil protein 2Rootletin-like