Ciliogenesis-associated TTC17-interacting protein (CATIP)

Ciliogenesis-associated TTC17-interacting protein (CATIP, gene symbol C2orf62) is a protein involved in the formation of primary cilia on cells by regulating actin filament dynamics and ciliogenesis[1][3][9]. It plays a critical role in the organization of the actin cytoskeleton, essential for cilium assembly and maintenance of sperm structure[3][5][7][9]. Pathogenic mutations in CATIP are linked to male infertility syndromes, particularly those involving abnormal sperm morphology and motility, such as oligoteratoasthenozoospermia (OTA) and spermatogenic failure 54, due to disrupted actin organization in sperm tails[1][5][9]. This protein does not directly fall into canonical categories such as receptor, enzyme, transporter, or transcription factor; instead, it is best classified as an intracellular structural/regulatory protein[9]. No known drugs, clinical biomarkers, or safety issues are currently associated with CATIP, and it is primarily of interest in rare genetic infertility disorders rather than as a therapeutic target[1][5][9].

Other names

C2orf62MGC50811Chromosome 2 open reading frame 62hypothetical protein LOC375307