Circulating plasma biomolecules

Circulating plasma biomolecules encompass the vast collection of proteins, lipids, metabolites, and signaling molecules found within the blood plasma (Source [1], [4]). This heterogeneous group includes major proteins such as albumin, which regulates oncotic pressure, and fibrinogen, which is essential for blood coagulation (Source [3], [7]). These biomolecules play critical roles in physiological processes including nutrient transport, immune defense, and systemic communication (Source [4], [8]). In clinical medicine, they serve as vital biomarkers for diagnosing and monitoring diseases like myocardial infarction, diabetes, and systemic inflammation (Source [3], [6]). While not a single therapeutic target, individual components within this category are frequently targeted by drugs to treat conditions ranging from hemophilia to hyperlipidemia (Source [5], [7]). For example, anticoagulants target specific clotting factors, while statins modulate lipoprotein levels (Source [4]). Furthermore, the interaction of these molecules with therapeutic agents, particularly nanoparticles, can significantly alter drug pharmacokinetics and biodistribution (Source [2]). Research into the plasma proteome and metabolome continues to identify novel specific targets for precision medicine (Source [5], [6]).

Other names

Plasma biomoleculesBlood plasma constituentsCirculating factorsPlasma proteome and metabolome

Therapeutic strategies involve the replacement of deficient plasma proteins, the inhibition of specific circulating enzymes or factors, and the modulation of lipid transport particles to treat systemic diseases (Source [4], [5], [7]).