Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Circumsporozoite Protein (Plasmodium vivax) (PvCSP)
- Target
- PvCSP
- Molecular classification
- Surface antigen, Glycoprotein
01
Overview
The circumsporozoite protein (CSP) is the most abundant surface protein on Plasmodium vivax sporozoites, the infectious form of the malaria parasite transmitted by mosquitoes. CSP is essential for parasite development, migration within the mosquito vector, and invasion of human hepatocytes during infection. It is a major target for neutralizing antibodies and a key vaccine candidate. Significant heterogeneity in its central repeat sequences among different isolates poses challenges for universal vaccine efficacy.
- Other names
- CSPPvCSPCircumsporozoite protein
02
Mechanism of action
Antibodies targeting CSP neutralize sporozoites and prevent liver cell invasion.
03
Biological functions
Sporozoite developmentSporozoite migrationHepatocyte invasionImmune response
04
Disease associations
MalariaInfection
05
Safety considerations
High genetic diversity limits universal vaccine efficacy.Antigenic variation across different Plasmodium vivax isolates.
Beyond the preview
Go deeper on Circumsporozoite Protein (Plasmodium vivax) (PvCSP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Circumsporozoite Protein (Plasmodium vivax) (PvCSP).