Citrate cycle enzymes

Citrate cycle enzymes" collectively refer to the suite of enzymes catalyzing the reactions of the citric acid (Krebs) cycle. These typically include (in order of the cycle): citrate synthase, aconitase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase[7][1]. Each of these enzymes plays a vital role in the oxidative metabolism of carbohydrates, fats, and proteins, resulting in ATP (energy) production and generation of key metabolic intermediates[3][5]. The enzymes are tightly regulated by substrate concentrations, allosteric effectors, and feedback inhibition, reflecting the cycle's centrality in energy balance and biosynthesis[5][8]. Dysregulation of citrate cycle enzymes is implicated in metabolic disturbances seen in cancer, cardiovascular, and neurodegenerative diseases[6]. Targeting individual enzymes (such as isocitrate dehydrogenase in cancer) can have therapeutic value, but "citrate cycle enzymes" as a group is not a specific drug target. Key points: - This is not a single molecule but a functionally defined group[7]. - Enzymes individually are targets (e.g., isocitrate dehydrogenase) but the group is not a canonical "target" for drugs or biomarker panels as a whole[7]. - The entry should be flagged as "is_incorrect: true" because it is too broad and non-specific to serve as a proper molecular target for the intended structured data.

Other names

Citric acid cycle enzymesKrebs cycle enzymesTCA cycle enzymes